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KMID : 0191120030180020295
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Journal of Korean Medical Science
2003 Volume.18 No. 2 p.295 ~ p.298
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Malignant Transformation of Intrathoracic Ancient Neurilemmoma in a Patient without Von Recklinghausen´s Disease
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Young Chae Chu/Young Chae Chu
Yong Han Yoon*/Hye Seung Han/Jee Young Han/Joon Mee Kim/In Suh Park
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Abstract
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Malignant transformation of a neurilemmoma is an exceedingly rare event. We describe a case of intrathoracic ancient neurilemmoma undergoing a malignant change in a 39-yr-old man. The patient presented with right flank and chest pain for several months. Plain radiography and CT scan of the chest showed a soft tissue mass lesion at the extrapleural space with erosion of surrounding ribs at the right basal lung area. The excised mass was encapsulated and measured 4.5 x 3.5 x 2.3 cm. The cut surface showed grayish-white and glistening with a focal cystic change and hemorrhage. Necrosis was not seen. Histologically, the tumor showed the features of classic neurilemmoma composed of the Antoni type A and B areas with perivascular hyalinization. In addition, obviously histo-logically malignant foci manifested by presence of markedly increased cellularity with fascicular arrangement, active mitotic activity, hyperchromasia, and gradual loss of original neurilemmomatous feature were noted.
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KEYWORD
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Neurilemmoma, Cell Transformation, Neoplastic, Neoplastic Processes,
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